Wishart Node

📢 One of the most cited articles in Nucleic Acids Research!
We are excited to share that our recent publication in Nucleic Acids Research — “The Natural Products Magnetic Resonance Database (NP-MRD) for 2025” — has become one of the journal’s most-cited recent articles, highlighting its strong impact and growing relevance across the scientific community.
The NP-MRD is a freely accessible, web-based platform designed for the deposition, sharing, and retrieval of NMR data on natural products. Originally developed to support compound de-replication and data sharing, it has rapidly evolved into a major global resource now widely used across metabolomics, microbiomics, foodomics, and nutrition science.
Since its launch, the database has seen remarkable growth:
📈 ~7× increase in compounds (281,859 total)
📊 ~7× increase in NMR spectra (5.5 million total)
🔬 Millions of predicted and simulated spectra added
🌍 Major expansion in global usage and community engagement
This growth has been matched by continuous improvements in data submission tools, spectral search capabilities, and analytical support—strengthening NP-MRD as a key infrastructure for the natural products community.
We are deeply grateful to all co-authors, contributors, and users who have helped make NP-MRD a widely used and highly cited resource.

The Natural Products Magnetic Resonance Database (NP-MRD) for 2025 Abstract. The Natural Products Magnetic Resonance Database (NP-MRD; https://np-mrd.org) is a comprehensive, freely accessible, web-based resource for the d

April is Parkinson’s Awareness Month 💙🧠
Parkinson’s disease is often recognized only after motor symptoms appear — but by then, underlying biological changes may have been developing for years.
A recent study highlights the potential of a five-metabolite blood-based signature, combined with early non-motor symptoms, to help identify Parkinson’s disease earlier and more accurately. This work underscores how metabolomics and biomarker discovery can support earlier detection, improved risk stratification, and more personalized approaches in neurodegenerative disease.
As we recognize Parkinson’s Awareness Month, this research reinforces the importance of advancing early diagnosis, systems biology, and precision health — not only for better outcomes, but for understanding disease long before clinical symptoms emerge.
Explore more here:

https://pubmed.ncbi.nlm.nih.gov/41565969

Association of a five-metabolite and early-symptom profile with Parkinson's disease and its clinical progression - PubMed Parkinson's disease (PD) urgently requires blood-based markers that flag pathology before disabling motor decline. This study measured absolute concentrations of 144 plasma metabolites in 20 neurologically healthy adults and in 40 PD patients clinically classified as intermediate (PD-I) or progressi...