Cordat Lab
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Page under construction These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance.
10/01/2025
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07/12/2022
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Our Story
Research in the Cordat’s lab is focused on trafficking of membrane proteins in cells, with a particular emphasis on bicarbonate transporters. These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance. Any imbalance of plasma bicarbonate homeostasis alters a number of physiological processes, including homeostasis of oxalate, a component of 80 % of kidney stones, indirect regulation of water reabsorption, plasma pH homeostasis, bile duct function, spermatogenesis, vision, hearing or cardiovascular function.
The Cordat’s lab has worked for many years on the kidney anion exchanger 1 (kAE1) protein. kAE1 mutations can be inherited and can induce a kidney disease called distal renal tubular acidosis (dRTA). This disease causes failure to thrive, muscle weakness and renal calculi. We currently work on further understanding the function and regulation of kAE1 but also of other bicarbonate transporters from the SLC26A gene family.
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