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The Prague Symphony (No. 38) by Mozart
The artistic richness of Prague does not consist only in the picturesque streets, churches, palaces, bridges and gardens. It's also renowned for its musical history.

http://www.theguardian.com/music/tomserviceblog/2013/oct/01/symphony-guide-mozart-38-prague-tom-service

The Prague Symphony (the Symphony No. 38) was composed by Wolfgang Amadeus Mozart in late 1786.
It was premiered in Prague on January 19, 1787, during Mozart's first visit to the city. Because it was first performed in Prague, it is popularly known as the Prague Symphony.

Symphony guide: Mozart's 38th - 'Prague' In the third in his symphony series, Tom Service goes back to 1786 Prague and Mozart's 38th symphony, in which you can hear the composer straining at the limits of what his orchestra, and the form, can do.