erickmosquera.ec

🚀 New Publication Alert 🚀
We are excited to share our latest study: “Acute nutritional ketosis during early recovery from aerobic exercise does not affect skeletal muscle transcriptomic response in humans” published in the European Journal of Applied Physiology.
Why this matter:

Ketone supplements are increasingly marketed as an ergogenic aid for recovery and adaptation, but the underlying molecular effects in muscle remain unclear.
What we did:
We conducted a randomized, double‐blind, crossover trial in recreationally active men. Participants completed 90 min of cycling at ~60% VO₂max followed by 3 hours of recovery. During exercise + recovery, they ingested either a ketone monoester (KME) or placebo. Muscle biopsies & genome‐wide transcriptomics were used to assess responses.
Key findings:
KME raised blood β‐hydroxybutyrate (ketone) levels significantly during recovery.
However, no differences were seen between KME vs placebo in:
🔸Skeletal muscle transcriptome (we measured nearly 17000 genes but no genes were differentially expressed due to KME)
🔸Glycogen resynthesis in muscle
🔸Erythropoietin (EPO) concentrations during early recovery
Implications:
While acute ketone supplementation does produce significant systemic metabolic changes (elevated ketones and reduced glucose), it does not seem to alter early post‐exercise gene expression in muscle under these conditions. It suggests that if ketones affect muscle adaptation, the mechanism is likely downstream of transcription, or requires longer duration/timing, or involves other levels of regulation (e.g. epigenetics, proteomics).
✔️ Thanks to the whole team José L Areta, , Jason P. Edwards, , Mark Viggars, for your hard work. Thanks to for the ongoing support.
📄 Read the free full open access paper here:
https://lnkd.in/dv5vAsmn

Team Potato, job done ✅
Thanks to .eco .gonzalezcr for your outstanding support throughout the whole research process of our Iris project (also known as the potato project)
From the jokes about potatoes, lab set ups, food delivery trips, recruitment, countless bottles, multiple coffees and muffins, until the storage of the last samples, you have done it all 🥔
Proud of watching you growing in your own unique ways, and looking forward to witnessing your next steps 🫂
Big thanks to all of our participants for your commitment and willingness to contribute with science
Finally thanks to my supervisory team, without whom I wouldn't be able to have a chance to be a PhD student
Jose Areta

Thanks to all the people who made it possible this ISAK Course Level 1 at Liverpool John Moores University.sportsnutrition - Without you this project would never have happened. Thanks for accepting my invitation and for making this course even better of what I had in mind.
Also thanks to the people who trust me a part of the learning journey of future Sports Nutritionist and Exercise Physiologist
Thanks to all the students for your effort and willingness. I am beyond grateful for the opportunity of learning together.
Thanks to me for the effort and love that I put into my dreams.