Genetics Center - VACSERA

a female patient who married at the age of 17 years. Her obstetric history is significant for gravida 5, para 1, abortus 4 (G5P1A4). She has one living daughter and a history of four spontaneous abortions..

cytogenetic study revealed:

46,XX,t(10;11)(p11.23;q23.3)
Female karyotype with a balanced reciprocal translocation between the short arm of chromosome 10 and the long arm of chromosome 11. No apparent gain or loss of chromosomal material is observed.
Balanced translocation carriers are typically unaffected but have an increased risk of generating unbalanced gametes, which may result in recurrent pregnancy loss or abnormal offspring.

** Preimplantation genetic testing for structural rearrangements (PGT-SR) or prenatal diagnostic testing in future pregnancies.
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