PREP lab

We are extremely pleased to share that our recent manuscript got published in Science Translational Medicine! In this study, we show from protein level to frontotemporal dementia (FTD) mouse model that PREP inhibition reduces Tau aggregation via direct interaction, and also via protein phosphatase 2A activation and autophagy. In the FTD-mouse, this led to disease-modifying effect and restoration of normal cognitive skills although the treatment was initiated by the time of symptom onset.

We want to acknowledge PREP lab members in University of Helsinki and University of Eastern Finland ( ), for this awesome work, and particulary my student and soon-to-be PhD Tony Eteläinen who made huge amout of work for the study. I'm also deeply grateful for Prof. Stephen Haggarty and Dr. Maria Catarina Silva, PhD for such a great collaboration with patient-derived cells.

Huge thanks to our long-term supporters Suomen Akatemia, , Business Finland and

A PREP inhibitor may help stop the progression of frontotemporal dementia Inhibition of the PREP enzyme was successful in stopping the progression of frontotemporal dementia in a mouse model of the disea. It also reduced the accumulation of Tau protein in neurons, which is typical of dementias.

Very happy to get a 3-year grant from Sigrid Juselius Foundation! We can start building up our research in UEF!

1–3-year grants - Sigrid Jusélius Foundation Application period at 23:59. Target groups The 1-3-year grants are targeted for two target groups for medical research: Senior researchers […]