RCSI Tissue Engineering Research Group

Juan Carlos Palomeque presenting his research entitled 'On-demand and scaffold-based delivery of miRNAs to enhance regenerative outcomes in chronic wound healing' as part of the Royal College of Surgeons in Ireland Research Day 2026!

Congratulations to Tara McGuire and everyone involved on the article 'Development of a PTEN-siRNA activated scaffold to promote axonal regrowth following spinal cord injury' recently published in Bioactive Materials! This study demonstrates that functionalising a collagen scaffold with PTEN-siRNA enhances the biomaterial's ability to promote neurite outgrowth.

Read the article here: https://www.sciencedirect.com/science/article/pii/S2452199X2600023X?via%3Dihub

Read the RCSI press release here: https://www.rcsi.com/dublin/news-and-events/news/news-article/2026/02/rcsi-researchers-develop-rna-activated-implant-to-stimulate-nerve-regrowth-after-spinal-cord-injury

This study was conducted in collaboration with the AMBER Centre and the IRFU Charitable Trust.

Congratulations to Head of TERG Fergal O'Brien and Dr Claudio Intini on the publication of their Nature Nanotechnology article 'Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis'!
Read it here:

Lesion-targeted, severity-responsive nanoparticle delivery for RNA therapy in osteoarthritis - Nature Nanotechnology Matrix-INverse Targeting (MINT) nanoparticles harness cartilage changes to deliver RNA therapies, reducing degeneration and pain in osteoarthritis.