KNOW YOUR Health

CASE STUDY: -ECLAMPSIA #

Preeclampsia is classically defined as the new onset of hypertension and proteinuria after 20 weeks of gestation.

New onset hypertension with significant end-organ dysfunction (with or without proteinuria) after 20 weeks of gestation also satisfies the diagnosis of preeclampsia.

SYMPTOMS

*Severe headache *epigastric or right upper quadrant pain
*visual disturbances *thrombocytopenia *impaired liver function *renal insufficiency *pulmonary edema

syndrome: *Hemolysis
*Elevated Liver enzymes, *Low Platelets

Edema may or may not be present.

🔸 = preeclampsia + seizures

Risk factors include:

*nulliparity
*past history of preeclampsia *preexisting hypertension or renal disease
*autoimmune disease *very young or advanced maternal age
*diabetes
* and obesity

⚠Curative treatment is

🔻Pathophysiology

Genetic and immunological factors
⬇
Defective spiral artery remodeling during pregnancy
⬇
During a normal pregnancy trophoblast cells invade the myometrial segment of the spiral arteries to cause transformation and dilation of the arteries.
⬇
In preeclampsia there is insufficient trophoblast cell invasion, which causes the spiral arteries to remain narrow and leads to placental hypoperfusion.
⬇
Diseased placenta releases proinflammatory proteins
⬇
Hypertension
Vasoconstriction
Endothelial cell dysfunction
Formation of thrombi
⬇
End-organ damage

NURSE KENT
_CARES_

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