M.T. Inter Lab

Malignant Hyperthermia (MH) is a serious and potentially life-threatening reaction to certain anesthetic medications used during general anesthesia. Although rare, this condition is considered a medical emergency and requires immediate treatment.

During an MH episode, the body develops:

* Rapidly rising body temperature
* Fast heart rate
* Muscle rigidity
* Abnormal metabolism and increased carbon dioxide production

💊 Medications that may trigger Malignant Hyperthermia include:

* Halogenated inhalation anesthetics such as Isoflurane, Desflurane, Halothane, and Sevoflurane
* Muscle relaxants such as Succinylcholine

Who should consider Malignant Hyperthermia (MH) genetic screening?
✔ Individuals with a family history of anesthesia-related complications
✔ Individuals with a family history of Malignant Hyperthermia
✔ Patients planning surgery or procedures requiring general anesthesia
✔ Individuals with muscle disorders or conditions associated with abnormal muscle function

🧬 “Genetic screening before surgery can help reduce anesthetic risk.”

Genetic testing allows physicians to assess the risk of MH and plan safer anesthesia management before surgery, helping improve patient safety and confidence.

Screening before surgery may help prevent serious complications.

Malignant Hyperthermia Screening by RYR1 and CACNA1S Genotyping
✔ Covers major genetic variants associated with Malignant Hyperthermia
✔ Uses internationally recognized gold-standard technology
✔ Simple testing procedure with rapid results
✔ One-time test with lifelong clinical value

For individuals interested in a more comprehensive pharmacogenetic assessment, we also recommend:

O300 Comprehensive Pharmacogenetics Panel

This panel includes genetic testing related to:

* Anesthetic drug reactions
* Antibiotic-related adverse reactions
* Gout medication sensitivity
* Other medication-related risks
* Pharmacogenetic guidance for medications used in:
* Heart disease
* Diabetes
* Hypertension
* Cholesterol management
* Depression
* Pain management

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