Apex Regenerative

Hip osteoarthritis is supposed to get worse. More pain. Less mobility. Progressive degeneration. But that’s not what happened in this regenerative biologics study.

Researchers took patients with established hip osteoarthritis and administered approximately 20 million culture-expanded autologous bone marrow mesenchymal stem cells once weekly for three weeks (60 million total whole stem cells). These weren’t young donor cells. They were the patients’ own adult bone marrow-derived cells. Patients were then followed for an average of 29 months.

The results:
•Significant improvements in pain
•Improved stiffness
•Improved physical function
•Improved range of motion
•90% of patients showed no radiographic progression of their hip osteoarthritis 🤔

In other words, the vast majority of patients did NOT continue down the expected trajectory of worsening degeneration during more than two years of follow-up.

What’s particularly interesting here is that this was accomplished with a relatively modest regenerative intervention: approximately 20 million adult autologous cells per treatment, administered three times…the source was a relatively poor regenerative source, the dose was relatively low. What they did right was prolong the treatment administration over weeks.

The future of potent regenerative medicine is not about a single injection. It’s about a cumulative regenerative signal, delivered over time, where dose, source, concentration, and protocol all matter. That’s what we’re helping our providers do every day. That’s what’s continuing to get significant clinical results.

Study: Mardones R, Jofré CM, Tobar L, Minguell JJ. “Mesenchymal Stem Cell Therapy in the Treatment of Hip Osteoarthritis”. Journal of Hip Preservation Surgery. 2017. https://pubmed.ncbi.nlm.nih.gov/28630737/

Comment “JOINT” to learn more.

If you’ve been researching NAD+, you’ve probably noticed something: Every NAD+ company talks about increasing NAD+. Very few talk about where that NAD+ is actually increasing.

NAD+ IVs, NR, NMN, and traditional NAD+ supplements are all evaluated (if studies have been done for them) based on how much they temporarily increase blood or plasma NAD+ levels. But NAD+ doesn’t perform its most important functions in your bloodstream. It performs them inside your cells.

Inside your cells, NAD+ helps drive:

•Cellular energy production
•Mitochondrial function
•DNA repair
•Recovery and resilience
•Healthy aging
•Neurological function

That’s why the data on our new Lathmized NAD+ (LNAD+) is so interesting.

LNAD+ is the first and only NAD+ product demonstrated in a randomized, placebo-controlled human clinical trial to increase intracellular NAD+ without increasing blood plasma NAD+.

The results:
✓ 53% increase in intracellular NAD+ in just 5 days
✓ 100% responder rate
✓ No increase in blood plasma NAD+

Additional research demonstrated:
✓ 42% increase in spinal cord NAD+ levels in 4 hours
✓ 300% increase in intracellular NAD+ levels in 30 days

Think about that for a moment. While most NAD+ products are showing temporary increases in circulating NAD+ markers, LNAD+ demonstrated measurable increases where NAD+ actually works: inside the cell. Not more NAD+ in the bloodstream. More NAD+ where energy production, mitochondrial function, DNA repair, and cellular resilience actually occur.

This is why we became interested in LNAD+. Not because of marketing. Because of the data.

Study DOI: https://doi.org/10.64898/2026.03.25.714130

Comment or DM “LNAD+” for more information.

For years, critics of regenerative medicine have argued that it doesn’t work.

The problem?

An abundance of published human literature says otherwise.

There are studies showing cartilage regeneration, tendon healing, meniscus regeneration, MRI-proven improvements, and durable clinical outcomes.

But that’s not the most interesting part.

The most interesting part is that many of those studies used only from 10 million to 100 million stem cells.

One treatment. One dose. 10-100M cells. That’s it.

Today, Apex providers START at 500 million zero-day-old placental mesenchymal stem cells worth of signaling and build protocols that ultimately deliver Billions of stem cells’ worth of signaling over time.

Most potent source. Highest dose. Repeated, daily exposure. Maximum healing opportunity.

If meaningful regeneration can occur with even 10 million to 100 million stem cells and a single treatment, why wouldn’t you expect more consistent, more dramatic, and longer-lasting outcomes when potency, dose, and frequency all increase?

Interested in learning more?

Comment “JOINT” today.