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What is Protonitazene?
The drug protonitazene is a new synthetic opioid structured similarly to etonitazene, a controlled synthetic opioid. Forensic casework encounters synthetic opioids with a different structure than protonitazene, namely he**in and fentanyl.

Protonitazene can come in the form of powder or tablets. It has also been found in syringes, indicating that the drug is available in all the standard forms of opioids.

Under closer examination, researchers believe that protonitazene is three times more potent than fentanyl. Fentanyl is responsible for hundreds of thousands of deaths, including over 92,000 deaths in 2020 alone.

Protonitazene is one of several drugs categorized as “nitazene” drugs. These drugs pose a public health threat for several reasons. One is that they may be resistant to overdose antidotes such as Narcan.

In addition, they are not controlled and have no approved medical use. Thus, there is no way of knowing how much protonitazene is being trafficked and used in the U.S. and Canada.