Sampson Lab for Kidney Genomics

The APOL1 gene has two known variants, G1 and G2, that are linked to increased risk of certain kidney diseases.

People who inherit two variants (G1/G1, G1/G2, or G2/G2) have a higher risk, but not everyone with two variants develops kidney disease. This tells us that G1 and G2 are only part of the story.

Studying APOL1 helps researchers understand why these variants affect people differently and how genetics and environmental factors together influence kidney disease risk and progression.

By learning more about genetic variation, researchers can work toward earlier detection, more personalized care, and better treatments for kidney disease.

Instead of studying one gene at a time, omics research looks at biology on a system-wide level, helping researchers better understand complex diseases like nephrotic syndrome. 🧬

Over the past 15 years, our work has contributed to more than 90 publications advancing kidney genomics research. Each study reflects the dedication of our team, the strength of our collaborations, and our shared commitment to better understanding kidney disease.

Wishing our community a warm and joyful Christmas 🎄✨!