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Stem cell therapy restores arm, hand movement for paralyzed man
Written by Honor Whiteman,

Medical News Today, September 8, 2016
A 21-year-old man left paralyzed after a spinal cord injury has regained the use of his arms and hands, thanks to an experimental stem cell treatment performed by researchers from the Keck Medical Center at the University of Southern California.
In March of this year, Kristopher (Kris) Boesen, from Bakersfield, CA, was involved in a car accident, in which he suffered severe trauma to his cervical spine that left him paralyzed from the neck down and unable to breathe without assistance.
Doctors told Kris that he might never regain the use of his limbs; current surgical procedures for spinal cord injury focus on stabilizing the spine to prevent further damage, but they rarely improve movement and sensation.
Kris then learned of a clinical trial – led by Dr. Edward D. Wirth III, chief medical director of Asterias Biotherapeutics – looking to enroll patients with spinal cord injury.
The ongoing trial is testing a novel therapy involving injections of AST-OPC1 – an agent consisting of oligodendrocyte progenitor cells (OPCs) that derive from embryonic stem cells. OPCs are the myelin-forming cells of the brain and spinal cord that help nerve cells to function.
According to Asterias Biotherapeutics – the developer of AST-OPC1 – preclinical trials of the agent in models of spinal cord injury have shown it leads to “reduction of the size of the injury cavity, restoration of the protective ‘myelin’ coating on nerve cells, production of factors that stimulate nerve cell growth, and recruitment of blood vessels to deliver oxygen and nutrients to the site.”
In order to take part in the trial – named “SCiStar” – patients need to be able to breathe without the help of a ventilator. Though it normally takes 3 weeks to wean a patient off assisted breathing, with the help of a dedicated respiratory team, Kris managed it in 5 days.
After further tests, he was confirmed as being eligible to take

http://www.medicalnewstoday.com/articles/312796.php

Stem cell therapy restores arm, hand movement for paralyzed man A man left paralyzed from a spinal cord injury has regained movement in his arms and hands as a result of a novel stem cell treatment.

Greeks Create Heart Cells from Stem Cells.

By Kerry Kolasa-Sikiaridi. Greek Reporter, Aug 20, 2016.

Researchers working with stem cells at Stanford University look to create heart cells from stem cells. The project, led by cardiovascular medicine instructor and Greek native, Dr. Elena Matsa, PhD, along with Joseph C. Wu, the Director of the Stanford Cardiovascular Institute and a professor in the Department of Medicine, is truly a revolutionary one.
According to Scopeblog.stanford.edu, in 2012 Dr. Matsa joined Joseph Wu’s laboratory with her current concentration in studying the molecular mechanisms of dilated cardiomyopathies, while trying to identify “genotype variations and pathways that may affect patient-specific disease progression and response to pharmacotherapy,” the site says.
In other words, Dr. Matsa has been doing research to show how closely stem cells replicate the function and gene expression of native tissues.
“We found that the gene expression patterns of the iPS cell-derived cardiomyocytes from each individual patient correlated very well. But there was marked variability among the seven people, particularly in genes involved in metabolism and stress responses. In fact, one of our subjects exhibited a very abnormal expression of genes in a key metabolic pathway,” Dr. Matsa explained.
The study also showed that the stem cells reacted differently in response to two different drugs that are associated with having adverse cardiac effects in some people, which is a vital usage of stem cells in research when doctors are trying to predict how patients will react to medicine.

Greeks Create Heart Cells from Stem Cells | USA.GreekReporter.com Researchers working with stem cells at Stanford University look to create heart cells from stem cells. The project, led by cardiovascular medicine instructor and Greek native, Dr. Elena Matsa, PhD, is truly a revolutionary one.