Cellular, Molecular and Biomedical Sciences - CMB Graduate Program at UVM

Congratulations Sierra!! 👏👏👏
Robert Larner College of Medicine UVM Graduate College

CMB @ UVM on Twitter “Congratulations to CMB student Sierra Bruno who successfully defended her dissertation titled, “Mitochondrial dynamic regulation of the lung epithelial response to complex allergen”👏👏👏 ”

In this recent article, the authors studied the effect of a mutation in Tau protein, R5L, associated with neurodegeneration. They discovered the R5L mutation is unlike other disease-associated mutations in Tau, challenging the current model of disease onset.
Congrats to CMB student Alisa Cario and the Berger Lab! 👏👏👏
Robert Larner College of Medicine UVM Graduate College

The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure - PubMed The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein motility, and participate in signaling cascades. Tau misregulation and point mutations are linked to neu...

Congratulations to CMB student J.J. Bivona who successfully defended his dissertation titled, "A multi-scale examination of skeletal muscle’s contribution to local and systemic immunomodulation." 👏👏👏

UVM Graduate College The Robert Larner, M.D. College of Medicine at The University of Vermont

Are mice a poor model for the human immune system, or are we just using the wrong mice? CMB student Snyder et al. used wild-derived mice to understand genetics of dendritic cell activation and metabolism, and discovered a novel Nos2 allele that behaves more like its human counterpart. UVM Graduate College

Divergent Genetic Regulation of Nitric Oxide Production between C57BL/6J and Wild-Derived PWD/PhJ Mice Controls Postactivation Mitochondrial Metabolism, Cell Survival, and Bacterial Resistance in Dendritic Cells - PubMed Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a requirement for survival in DC subsets that express inducible NO synthase (Nos2) due to NO-mediated inhibition of mitochondrial respiration. This phenomenon primarily has been studied in DCs from t...

Check this hot-off-the-press article by University of Vermont Cancer Center researchers that show an induction of an ATR DNA damage response and telomere shortening in Vero E6 cells by SARS-CoV-2 infection!!!

SARS-CoV-2 triggers DNA damage response in Vero E6 cells - PubMed The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible for the current COVID-19 pandemic and has now infected more than 200 million people with more than 4 million deaths globally. Recent data suggest that symptoms and general malaise may continue long after the inf...