Bruce R. Talbot Associates LLC

FDA Issues Warning to Distributors of 7-OH

The FDA has sent warning letters to companies illegally selling 7-hydroxymitragynine (7-OH), a potent opioid-like substance found in trace amounts in kratom but often sold in concentrated forms like tablets, gummies, or shots.

7-OH is a psychoactive compound found naturally in Kratom that acts on opioid receptors in the brain, similar to narcotics like he**in. It’s much stronger than plant based kratom’s other components, making it highly addictive and dangerous when concentrated.

7-OH produces rapid euphoria, pain relief, and sedation, but it can also cause severe opioid-like effects, including respiratory depression and intense withdrawal symptoms.

Serious Side Effects associated with 7-OH use include liver damage, seizures, heart failure, and addiction.

Users report cravings, irritability, and physical dependence when trying to stop using the drug.

One death has been linked to a 7-OH product, plus numerous hospitalizations due to seizures, liver issues, and substance use disorders.

7-OH is often abused by adults seeking a replacement to opioid pills, he**in or fentanyl abuse, or to manage opioid withdrawal. However, it’s increasingly popular in smoke shops and online, attracting a wide range of users, including those unaware of its risks.

The FDA has reported multiple emergency room visits tied to 7-OH products, including cases of severe sedation and respiratory issues. One confirmed death was linked to a product containing 7-OH.

Several states have banned or restricted 7-OH and kratom including; Alabama, Arkansas, Indiana, Rhode Island, Vermont, Wisconsin.
Other states, Arizona, Oklahoma, Texas, and Utah have specific restrictions: (bans on synthetic 7-OH exceeding 2% alkaloid content), plus nine other states with specific regulations.

Stay safe and avoid unapproved 7-OH products! The FDA warns these are not safe or legal for medical use.

"Pink Co***ne": Another Trendy Street Drug Emerging in Florida

In recent months, reports have surfaced about a street drug known as "pink co***ne" gaining traction in parts of Florida. Despite its name, this substance is not related to traditional co***ne but is often linked to synthetic drugs with potentially dangerous effects. Here's what you need to know about this growing phenomenon.

What is Pink Co***ne?

Pink co***ne, also referred to as "tusi" or "tucibi," is a synthetic drug that usually appears as a brightly colored powder, sometimes pink, hence the name. Its composition varies significantly, as it is often a mixture of substances, which may include M**A (ecstasy), ketamine, amphetamines, or other chemicals. This inconsistency makes it highly unpredictable and dangerous.

Origins and Appeal

The drug's origins can be traced back to Colombia, where it was initially marketed as a designer drug for affluent partygoers. Its colorful appearance and association with nightlife have contributed to its appeal, especially among younger populations. However, its spread to the United States, including Florida, has brought increased risks due to limited regulation and unknown ingredients.

The Risks

The primary danger of pink co***ne lies in its unpredictability. Users often do not know what they are consuming, as the drug can be laced with highly potent and harmful substances such as fentanyl. Reported side effects include hallucinations, rapid heart rate, confusion, anxiety, and, in severe cases, respiratory distress or overdose.

The dangers of pink co***ne were highlighted in the tragic death of former One Direction singer Liam Payne in October 2024. Toxicology reports indicated multiple substances in his system, including pink co***ne, shedding light on the unpredictable and hazardous nature of this synthetic drug.

Law Enforcement and Public Health Concerns

Law enforcement agencies in Florida have expressed concern about the rising availability of pink co***ne. Its popularity at parties and festivals makes it difficult to monitor and regulate. Public health experts are urging awareness campaigns to educate people about the risks associated with using synthetic drugs.

Prevention and Support

If you or someone you know is struggling with substance use, resources are available to provide help and guidance. Contact organizations like the Substance Abuse and Mental Health Services Administration (SAMHSA) at 1-800-662-HELP (4357) for confidential support.

As awareness of pink co***ne grows, it’s crucial to approach the issue with education and prevention efforts to reduce harm and save lives.
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Very interesting news on the effect of the new class of weight loss drugs, commonly known as "GLP-1 drugs" on substance abuse addiction.

Very early research studies have shown that GLP-1 drugs may reduce cravings and relapse rates for alcohol, co***ne, and ni****ne. Although more research is needed, these early findings are very exciting for the field of addiction treatment.
Citation:

The role of glucagon-like peptide 1 (GLP-1) in addictive disorders - PubMed Drug, alcohol and to***co use disorders are a global burden affecting millions of people. Despite decades of research, treatment options are sparse or missing, and relapse rates are high. Glucagon-like peptide 1 (GLP-1) is released in the small intestine, promotes blood glucose homeostasis, slows ga...