Borchert Lab

Super proud of our ASMS team!

Borchert lab releases preprint detailing the first-ever experimental demonstration that genomic enhancers target specific promoters through direct DNA:DNA interaction.

Jeffrey D DeMeis, Justin T Roberts, Haley A Delcher, Noel L Godang, Alexander B Coley, Cana L Brown, Michael H Shaw, Sayema Naaz, Enas S Alsatari, Ayush Dahal, Shahem Y Alqudah, Kevin N Nguyen, Anita D Nguyen, Sunita S Paudel, Hong Dang, Wanda K O'Neal, Michael R Knowles, Dominika Houserova, Mark N Gillespie, Glen M Borchert. Long G4-rich enhancer physically interacts with EXOC3 promoter via a G4:G4 DNA-based mechanism. bioRxiv 2024.01.29.577212; doi: https://doi.org/10.1101/2024.01.29.577212

Long G4-rich enhancer physically interacts with EXOC3 promoter via a G4:G4 DNA-based mechanism Enhancers are genomic sequences that function as regulatory elements capable of increasing the transcription of a given gene often located at a considerable distance. The broadly accepted model of enhancer activation involves bringing an enhancer-bound activator protein complex into close spatial pr...

Dr. Glen Borchert was recently interviewed by the National Science Foundation regarding his current research efforts and what we can be doing to prepare for the next pandemic. This 30 minute podcast was published June 5.

https://podcasters.spotify.com/pod/show/science-before-the-storm/episodes/Unlock-Your-Superpower-How-Looking-for-Four-Leaf-Clovers-Can-Reveal-the-Potential-of-Non-Coding-RNA-e23gcqc