Farber Lab

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Home The Farber Lab is located in the Columbia Center for Translational Immunology at the Columbia University Irving Medical Center. Dr. Farber is in the Department of Surgery and the Department of Microbiology and Immunology at the Columbia University Vagelos College of Physicians and Surgeons. The lab...

Our paper on lung tissue resident memory T cells and allergic asthma is published online in the Journal of Immunology, with Damian Turner as first author and in collaboration with Drs. Monica Goldklang and Jeanine D'Armiento

Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma Asthma is a chronic inflammatory disease mediated by allergen-specific CD4 T cells that promote lung inflammation through recruitment of cellular effectors into the lung. A subset of lung T cells can persist as tissue-resident memory T cells (TRMs) following infection and allergen induction, althoug...

Our study identifying a unifying signature for human tissue resident memory T cells was published in Cell Reports

www.cell.com

Our study on mechanisms for altered infant respiratory immunity was published today in the Journal of Experimental Medicine

Reduced generation of lung tissue–resident memory T cells during infancy Infants suffer disproportionately from respiratory infections and generate reduced vaccine responses compared with adults, although the underlying mechanisms remain unclear. In adult mice, lung-localized, tissue-resident memory T cells (TRMs) mediate optimal protection to respiratory pathogens, and…

Our collaborators on our NIH program grant, Drs. Nina Luning-Prak (UPenn), Uri Hershberg (Drexel) and Mark Shlomchik (U. Pitt.) just published an elegant study revealing B cell clonal distribution throughout the human body.
http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3942.html

An atlas of B-cell clonal distribution in the human body : Nature Biotechnology : Nature Research

Elemental Haiku in Science magazine

Elemental haiku Author Mary Soon Lee (marysoonlee{at}gmail.com) provides this review of the periodic table composed of 119 science haiku, one for each element plus a closing haiku for element 119 (not yet synthesized). The haiku encompass astronomy, biology, chemistry, history, physics, and a bit of whimsical flair