Williams Lab

Huge congratulations to Zhongtian Zhang (aka Nemo) who passed his final defense! Dr. Zhang will soon begin work at Amyris. Nemo was a trainee of the Microbiology Graduate Program at NC State. His work involved the identification, characterization, and application of a novel CRISPR-Cas system. Ph.D. #14 for the Williams Group!

Excited to announce our latest publication and collaboration with the Fourches group at NC State Chemistry, “SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides”. This advance allows in silico libraries of macrolides to be constructed based on the knowledge of polyketide biosynthesis. It’s a first step towards the generation of new bioactive macrolides by combining synthetic biology and computational chemistry.

SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides We report on a new cheminformatics enumeration technology—SIME, synthetic insight-based macrolide enumerator—a new and improved software technology. SIME can enumerate fully assembled macrolides with synthetic feasibility by utilizing the constitutional and structural knowledge extracted from bi...