Santa Barbara Nutrients

Interim Clinical Trial Results Show Significant Efficacy of KetoCitra® in Combination With Nutritional Changes in Autosomal-Dominant Polycystic Kidney Disease

Interim results from a controlled clinical trial presented at ASN offer evidence for metabolic therapy in ADPKD.
The study, led by Juntendo University in Tokyo, tracked the efficacy of KetoCitra® as part of the Ren-Nu™ ketogenic nutrition program.

Key Findings at 3 Months:
-Clinically Meaningful Kidney Volume Decline: Subjects in the intervention group experienced a statistically significant 5.01% reduction in Total Kidney Volume (TKV). During the same period, the control group’s kidneys grew by 8.03%
-Renal Function Stability: The intervention group showed a stabilization of eGFR (+0.59 ml/min/1.73 m²), while the control group continued to show a decline (-1.57 ml/min/1.73 m²).
-High Tolerability and Adherence: The study reported a 100% adherence rate, with zero participants discontinuing.

The Mechanism:
Targeting the metabolic vulnerability of cystic cells (glucose dependency) via nutritional ketosis, supported by the exogenous ketone BHB and alkaline citrate to normalize urinary pH.

Conclusion:
A non-pharmacological approach that is clinically safe, effective and feasible for patients.

Interim Clinical Trial Results Show Significant Efficacy of KetoCitra® in Combination With Nutritional Changes in Autosomal-Dominant Polycystic Kidney Disease FOR IMMEDIATE RELEASE SANTA BARBARA, CA – Santa Barbara Nutrients (SBN) is pleased to announce the first interim results from an ongoing clinical trial to study the safety and efficacy of SBN’s medical food KetoCitra® in combination with education on ketogenic nutrition and lifestyle changes in...

New video about the work of the PKD Free Alliance.

Melina Messing, Scientific Director of Ren-Nu at Santa Barbara Nutrients, talks to Kevin Schnurr and Melinna Sanchez from the PKD Free Alliance about their program to support in vitro fertilization services for individuals with polycystic kidney disease.

PKD-Free Alliance at ASN Kidney Week Melina Messing, Scientific Director of Ren-Nu at Santa Barbara Nutrients, talks to Kevin Schnurr and Melinna Sanchez from the PKD-Free Alliance about their p...

📢 Santa Barbara Nutrients is looking for people who would like to help in our marketing efforts! The only requirements are that you have a deep interest in polycystic kidney disease, and have a basic understanding of marketing and social media (you do not need to be an expert). This role will provide the unique opportunity to work with a team of PKD scientists, nephrologists, dietitians, and people affected by PKD (we already have 11 on the team!). So if you are interested or have questions please email us at [email protected].

Thank you to SBN Practitioner Network Member, frequent SBN Blog Post writer and Medical Director of Integrative Kidney Solutions, .isreb for reviewing these highly encouraging interim results from the first ketogenic diet study on Japanese ADPKD patients utilizing KetoCitra®. We appreciate all that you do for SBN and Renal Health! Don’t miss his latest SBN Guest Blog Post at link below:
🔗https://santabarbaranutrients.com/blogs/kidney-health/three-month-interim-analysis-of-ketogenic-metabolic-therapy-in-japanese-adpkd-patients