Project Violet

We're very excited to announce the results of the largest high-risk medulloblastoma trial were published today in JAMA Oncology. In a huge collaborative effort, we have evidence for a new treatment that increases survival by nineteen percent!!

In the words of Dr. Jim Olson himself, "Since the advent of radiation and chemotherapy over a half century ago, we’ve never seen this big of an improvement in one clinical trial for kids with brain tumors, to my knowledge. From this point forward [...] 20 more children out of every 100 will survive the disease than would have survived in the past. It’s a forever improvement, and it gives us a clear roadmap for the future."

If you want to read more of the story, check out this blog article: https://pulse.seattlechildrens.org/the-largest-medulloblastoma-trial-makes-monumental-strides-forward-for-cancer-research-increases-survival-in-children-by-19-percent/

The scientific paper can be found here: https://jamanetwork.com/journals/jamaoncology/fullarticle/2782033

The Largest High-Risk Medulloblastoma Trial Makes Monumental Strides Forward for Cancer Research, Increases Survival in Children by 19 Percent Seattle Children’s is excited to announce results published today in JAMA Oncology.

More congratulations are in order as members of Project Violet graduate to bigger and better things. We are excited to see Dr. Nick Vitanza starting his own lab at Seattle Children's where he will be joined by a couple talented members of the Olson lab, Matt Biery and Carrie Myers. We will sorely miss them in the lab, but are also extremely proud to see them move on and continue the fight against pediatric brain cancer.

Nick Vitanza on Twitter “The first delivery. Currently fighting the urge to open and organize everything myself but determined to have a Christmas morning gift opening with the team when they officially start on Tuesday!”

Another exciting publication from the Olson lab investigating the role of the immune system in the recurrence of pediatric brain cancer. Thanks for all your support in our pursuit of helping kids survive the unthinkable and please join me in congratulating the team!

Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival Purpose Tumor infiltration by immunosuppressive myeloid cells or tumor-associated macrophages (TAMs) contributes to tumor progression and metastasis. In contrast to their adult counterparts, higher TAM signatures do not correlate with aggressive tumor behavior in pediatric brain tumors. While promin...

More cutting-edge research sponsored by Project Violet towards the development of personalized medicines was accepted for publication recently. Congratulations to the team and all involved!

https://www.frontiersin.org/articles/10.3389/fimmu.2021.658372/abstract