Institute for Systems Biology

How does the immune system recognize viruses and cancer — and how can scientists study those responses in greater detail?

A new study from ISB researchers introduces a high-throughput platform that can identify and deeply profile antigen-specific CD4+ T cells at single-cell resolution.

The work, published in Nature Portfolio's Nature Communications, could help improve vaccine design and advance future cancer immunotherapies.

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A New Window Into the Immune System: ISB Researchers Develop Powerful Platform to Decode CD4+ T Cells A new high-throughput platform profiles antigen-specific CD4+ T cells at single-cell resolution for vaccine and cancer research.

What if we’ve been missing a major part of human biology?

Scientists — including researchers at the Institute for Systems Biology — have identified more than 1,700 new protein-like molecules hidden within the human genome.

These newly discovered molecules, called “peptideins,” expand our understanding of the human proteome and could have important implications for cancer, immunotherapy, and other diseases.

This work opens the door to an entirely new area of biology — and potentially new approaches to diagnosing and treating disease.

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Scientists Uncover 1,700+ Protein-like Molecules in the ‘Dark Proteome’ Scientists identify 1,700+ new protein-like molecules in the human genome, revealing a hidden layer with implications for cancer and disease.