Lombardi Comprehensive Cancer Center

At Lombardi Comprehensive Cancer Center, groundbreaking cancer research is powered by collaboration, innovation and a commitment to caring for the whole person. From breast cancer and hereditary cancer research to biomedical informatics and cancer aging studies, Georgetown Lombardi’s research centers are advancing discoveries that shape the future of prevention, treatment and survivorship. Learn more about our Research Centers and how their work is transforming lives across our communities: https://lombardi.georgetown.edu/research/centers/

Research Centers - Lombardi Comprehensive Cancer Center The Nina Hyde Center for Breast Cancer Research, established in 1989 as a tribute to a former fashion editor of The Washington Post, uses a collaborative, multidisciplinary approach to conduct cutting-edge breast cancer research.

Researchers at Georgetown’s Lombardi Comprehensive Cancer Center have identified a mechanism that may help explain a key reason why older people experience worse outcomes from breast cancer. The study implicates RAGE (Receptor for Advanced Glycation End-products), a cell surface receptor that amplifies inflammatory signaling, and which also becomes increasingly active with metastatic progression. “Our study addresses a major gap by showing that aging dramatically increases breast cancer metastasis, and that this effect depends on RAGE, a receptor on the surface of cells that fuels inflammation,” says Barry Hudson, PhD, associate professor of oncology at Georgetown Lombardi and corresponding author for this article. The finding appeared in the Nature journal Communications Biology. Learn more: https://lombardi.georgetown.edu/news-release/study-reveals-why-breast-cancer-becomes-more-deadly-with-age/

Age and Breast Cancer Outcomes - Georgetown Lombardi Researchers at Georgetown Lombardi have identified a mechanism that may help explain why older people experience worse outcomes from breast cancer.